Eddie Murphy stars as Dr. Sherman Klump, a kindhearted, brilliant genetics professor whose 400-pound frame makes him painfully self-conscious. Desperate to win the affection of his new colleague, Sherman develops an experimental serum that transforms him into his slimmer, more confident alter ego, Buddy Love. Murphy delivers a tour-de-force comic performance, playing multiple members of the Klump family alongside his unforgettable dual roles.